氨酰心安及吲达帕胺对高血压病患者甲襞微循环的影响

The Effects of atenolol and indapamide on nailfold microcirculation in the patients with essential hypertension

本文对比观察氨酰心安和吲达帕胺对高血压病患者甲襞微循环的影响。治疗前高血压组甲襞微循环各项积分值及总积分值均显著高于正常对照组。氨酰心安治疗后．除周状态积分值降低外，其余各项积分值及总积分值均无显著变化；甲襞微循环血管密度及血流速度也无明显改变。吲达帕胺治疗后，甲襞微循环各项积分值及总积分值均显著降低；微血管体积密度、线密度显著增加．血流速度明显增快。本研究表明氨酰心安对高血压病患者甲襞微循环无显著影响，吲达帕胺可显著改善高血压病患者甲襞微循环。

Changes of the nailfold microcirculation were investigated in the hypertensive patients treated with atenolol and indapamide respectively. The results showed that the score values of morphology. hemodynamics,status of perivascular tissue and the total score values in the hypertensive patients before treatment were significantly higher than those in normal persons.Except the score value of perivascular status, there were no significant changes in all other score values of the nailfold microcirculation in hypertensive patients treated with atetolol.After indapamide treatment .all score values of the nailfold microcisrculation decreased significantly, and the mnicrovessels density and blood flow increased significantly. This paper suggested that indapamide can improve significantly the nailfold microcirculation of hypertensive patients,whereas atenolol exhibits no such effect.