复方骨基质胶修复骨缺损实验研究

AnExperimentalStudyofRepairmentofBoneDefectswithCompoundBMG

目的：骨基质胶（ＢＭＧ）的诱导成骨作用已明确，本实验的目的在于进一步探讨其他具有成骨作用的物质对其诱导成骨作用的影响。方法：采用ＢＭＧ加微量元素、丹参的复方制剂与单一制剂对骨缺损修复的Ｘ线片、光镜及电镜的组织学对比观察。结果：该复方制剂能使骨痂出现及骨性连接时间较单独使用ＢＭＧ提前２～４周，且前者成骨效果明显优于后者。结论：复方ＢＭＧ成骨作用增强可能不仅仅是单一制剂成骨作用的叠加，而是协同作用的结果，即微量元素及丹参可以增强ＢＭＧ的成骨活性，但有待于进一步研究证实。本实验结果提示，对临床骨折、骨缺损及骨不连病人。

Aim:TheinductiveefectsofBMGhasbeenproven.Thisexperimentwascariedouttoinvestigatesomeothermaterialsthathaveboneformationpotentialimpact.Methods:ThecompoundBMGwasprocessedbyaddingtraceel-ementandRadixsalviaemiltiorrhizaetoBMG,thenthroughtheroentgenographandhistologicalchangesoflightandelec-tronicmicroscope,theefectsofcompoundBMGonbonedefectsrepairmentandtheefectsofeachsingleproductswerecomparelyobserved.Results:Theresultsrevealedthatthecalusandboneformationappeared2-4weeksearlierinthecompoundBMGgroupthanintheBMGgroup,andtheefectsofboneformationinthecompoundBMGgroupexceledthatintheBMGgroup.Conclusion:TheefectofcompoundBMGonboneformationisconsideredtobenotthesimpleaccumu-lativeeffectofeachproductbutthecooperativeresultofeachproduct,forthetraceelementsandRadixsalviaemiltiorrhizaecanpromotetheactivityofboneformationofBMG.Butthisneedstobefurthertested.Theresultindicatedthatmoresat-isfactoryefectscouldbeobtainedbyusingcombinedpreparationsofseveralproductsthatcanpromoteboneformationinclinicaltreatmentoffractureandbonedefects.