急性脑外伤患者血浆前列腺素F2α的含量变化及临床意义

AlteredLevelandClinicalSignificationofPlasmaPGF2αinAcuteBrainInjuryPatients

目的：测定脑外伤患者血浆前列腺素Ｆ２α含量变化，探讨其临床意义。方法：对６５例不同严重程度的急性脑外伤病人在伤后第１、３、７、１４天用放免法连续检测其血浆前列腺素Ｆ２α（ＰＧＦ２α）的含量。其中重型颅脑损伤３５例，中型１３例，轻型１７例。并测定２６例健康人血浆ＰＧＦ２α含量作对照组。结果：外伤组血浆ＰＧＦ２α含量升高明显，损伤程度越重，ＰＧＦ２α含量升高幅度越大，持续升高的时间越长，重型损伤组在２周内的含量始终高于对照组水平。从预后分组观察，死亡组和预后不良组其ＰＧＦ２α升高明显，死亡组在第１４天的含量仍维持在高水平状态。结论：根据实验结果认为。

Aim:ToevaluatethechangesoftheprostaglandinF2αlevelsintheplasmaofbraininjurypatients.Meth┐ods:Inthisstudy,theplasmalevelsofprostaglandinF2α(PGF2α)weremeasuredbyRIAinthe65patientswithacutebraininjuryat1st,3rd,7thand14thdayafterinjury,TheplasmalevelsofPGF2αin26healthesweremeasuredascontrol.Results:PGF2αlevelwaselevatedinthevictimsthanthecontrol.TheseverityofheadinjuryhadacloserelationshipwithplasmaPGF2αlevels.ThehigherPGF2αlevel,themoreseveritybraininjurywas.IfthePGF2αlevelswereelevatedfor7-14days,theneurologicaloutcomewaspoor.Amongthreepredictinggroups,thePGF2αlevelsofdeathandpooroutcomegrouproseobverouslyaftertheinjury,andthePGF2αlevelwasstilraisedindeathgroupat14dayaftertheinjury.Conclu┐sion:TheplasmalevelsofPGF2αcouldbeasignificantindexforjudgingtheinjuryconditionandprognosisofthepatientswithacutebraininjury.