摘要
用T-2毒素和低硒饲料喂养雏鸡,经组织化学方法观察软骨胶原和蛋白多糖含量的变化,结果发现,与对照组相比,低硒饲料组、T-2毒素组、T-2毒素加低硒组Ⅱ型胶原蛋白和硫酸软骨素、硫酸角质素含量均减少,Ⅰ型胶原含量增加,以T-2毒素加低硒组变化最为显著,低碱饲料组变化最小,而T-2毒素补硒组各项指标均接近正常。提示低硒和T-2毒素对软骨基质均有毒性作用,低硒能增强T-2毒素;硒;胶原蛋白;软骨素;
The relative quantitative changes of collagen and proteoglycan in cartilage were studied with histochemistry method after feeding chickens with T 2 toxin and/or low selenium diet.The contents of collagen type Ⅱ,chondroitin sulphate and keratin sulphate decreased,while the contents of collagen type Ⅰ increased in low selenium group,T 2 toxin group and T 2 toxin plus low selenium group,as compared with the normal control group.The contents of collagen type Ⅰ and type Ⅱ,chondroitin sulphate and keratin sulphate in the high selenium plus T 2 toxin group all approximated to those of normal control group.The results demonstrate that both low selenium and T 2 toxin have toxic effects on cartilage,and the toxic effect of T 2 toxin is enhanced by low selenium.Increasing the selenium content in the food can antagonize the toxic effect of T 2 toxin on cartilage.
出处
《军事医学科学院院刊》
CSCD
北大核心
1996年第1期26-29,共4页
Bulletin of the Academy of Military Medical Sciences