HLA─Ⅰ类与Ⅱ类抗原在食管癌与肝癌中的分布

Distribution of HLA class Ⅰ and HLA class Ⅱ antigens in cancers of liver and esophagus

用间接过氧化酶免疫组织化学法，以抗ＨＬＡ－Ⅰ类分子，抗β２－微球蛋白，抗ＨＬＡ－Ⅱ类分子，抗ＨＬＡ－ＤＲ－ＤＰ－ＤＱ亚分子等单克隆抗体１２种（ＳＦ１～１２）检测食管鳞状上皮癌及原发性肝癌且织细胞的各类抗原表达。结果表明，２０例食管鳞状上皮癌全部表达ＨＬＡ－Ⅰ类分子及β２－微球蛋白。６０％表达ＨＬＡ－Ⅱ类分子。５例原发性肝癌同样高强度地表达了ＨＬＡ－Ⅰ类抗原，但β２－微球蛋白显示弱反应。

Twelve monoclonal antibodies against HLA class Ⅰ,β 2 microglobulin,HLA class Ⅱ and HLA DR DP DQ submolecules wee used to test the expression of corresponding antigens in esohageal cancer.The results showed that HLA class Ⅰ molecule and microglobulin were expressed in all of 20 cases,in which 60% exhibited HLA class Ⅱ molecules.Likewise 5 cases of primitive liver cancer highly expressed HLA class Ⅰ antigens.The reaction to β 2 microglobulin was weak.Its expression was found in certain liver cancers.