烟酸注射液对脂肪栓塞综合征防治作用的实验研究

Prevention and treatment effect of niacin on FES : experimental study

试图在用同种异体犬骨脂肪建立脂肪栓塞综合征动物模型的基础上，探索烟酸注射液对ＦＥＳ的防治作用。方法将１４只犬分治疗组和对照组，对照组只单纯静脉注射骨髓脂肪，而治疗组在注射骨髓脂肪的同时，静脉滴入烟酸液４ｍｇ／ｋｇ，每８小时一次，连续观察４８小时。

Objective On the basis of fat embolism syndrome animal model injected with homologous dog bone marrow fat , we probed into the preveotion and treatment effect of niacin on FES, Methods Fourteen dogs were divided into experimental group and control group. In the experimental group , the dogs were injected with homologous dog bone marrow fat accompanied by niacin injection 4mg/kg. 8hr intravenously for 48 hours , while in the control group , only bone marrow fat was injected. paO_2 , FFA , triglyceride , platelet counts , fat drops in the blood clots of vein were examined at different times. Final- ly , morphology and pathology of the lungs were observed . Results There were a slower decrease in PaO_2 and platelet counts and no obvious increase in triglycarid and FFA in the experimental group. The amount and diameter of fat drops in the blood clots of vein and in the lungs were less in the experimental group than in the control. Pathological examinations of the lungs demonstrated much less injuries in the experimental group. Conclusion Good prevention and treatment effect of niacin on fat embolism syn- drone is suggested .