青少年钙负荷的降压效应研究

Study on Hypotensive Effect and Its Mechanism with Calcium Supplementation in Adolescents

对９６名１４～１７岁学生进行了２个月的钙干预试验。在实验前后进行体格指标、血清及尿电解质、血浆维生素Ｄ３、血小板内Ｃａ（２＋）及Ｍｇ（２＋）的测定。结果表明：青少年血压与皮脂厚度、脉率、血小板内Ｃａ（２＋）及尿Ｃａ（２＋）呈显著正相关关系（ｒ＝０．２７～０．３３，Ｐ＜０．０５）；血压下降与血浆维生素Ｄ３、肾排Ｎａ＋能力呈负相关关系（ｒ＝－０．４２～－０．４４．Ｐ＜０．０５）；血小板内Ｃａ（２＋）与舒张压下降，尿Ｎａ＋与有家族史组血压下降关系密切。提示钙负荷对青少年有显著的降压作用，但降压作用具有选择性。

The purpose of this article was to study whether calcium supplementation has hypotensive effect in adolescents.The effect of 8-week oral calcium loading on blood pressure was studied in 96 adolescents,aged 14 to 17.The physical examinations and measurements,which include electrolytes in serum and urine, plasma VitD3,intraplatelet Ca and Mg,were carried out respectively before and after the study for the adolescents.It was found that blood pressure in adolescents positively correlated with fat thickness, pulse rate,levels of intraplatelet Ca and urine Ca(r=0.27～0.33,P<0.05):the decrease of blood pressure was negatively correlative to plasma VitD3 and urine Na( r=-0.42～-0.44,P <0. 05,especially blood pressure decrease in group with family hypertension history to urine Na. The decrease of diastolic blood pressure is closely related to intraplatelet Ca. The results suggest that calcium supplement can significantly reduce blood pressure in adolescents,but this action has selection.