麦冬皂苷研究Ⅶ·麦冬皂苷肠溶微球的释放度研究

Ophiopogon samponin Ⅵ·Release rate of ophiopogon saponin enteric microsphere

目的:探讨微球的释放度影响因素,为制剂成型提供依据。方法:采用喷雾干燥法制备麦冬皂苷肠溶微球,以比色法测定微球在酸中及缓冲液中麦冬总皂苷的累积释放度。结果:随着丙烯酸树脂Ⅱ(囊材)浓度的增加,累积释放度呈下降趋势。突释效应的达峰时间随着药物与囊材比的增大而延缓。结论:囊材浓度、药物囊材比为影响微球在酸中及缓冲液中累积释放度的主要影响因素。

AIM： To explore the influencing factors in the release rate and give the application to the preparation. METHODS ： Preparing ophiopogon saponin enteric microsphere by spray drying process, the accumulative release rate of acid and buffer solution were detected by colorimetric analysis. RESULTS ： With the increase of Eudragit Ⅱ concentraction, the accumulative release rate tended to decrease. But ratio of drug and Eudragit Ⅱ , increased with the decrease in delay time on the break point. CONCLUSION ： The concentration of Eudragit and the ratio of drug and material are the rey factors in the accumulative release rate in acid and buffer solution.