抗支清肺汤治疗支原体肺炎的临床研究

The Clinical Study on The Treatment of Mycoplasmal Pneumonia by Kangzhiqingfeitang

[目的]通过观察抗支清肺汤对支原体肺炎患儿临床症状的改善以揭示其疗效,进行免疫学分析以研究其作用机理。[方法]选择120例患者随机分为治疗组60例和对照组60例。治疗组以抗支清肺汤治疗,对照组采用阿奇霉素治疗。[结果]总有效率治疗组为90%,对照组为87%,两组比较,差异有显著意义(P<0·01),治疗组明显优于对照组。治疗组在退热,咳嗽消失等方面明显优于对照组。治疗组治疗前后外周血CD4水平有显著性差异(P<0·05),CD8、CD4/CD8水平有非常显著性差异(P<0·01)。对照组治疗前后外周血CD4、CD8、CD4/CD8水平无显著性差异(P>0·05)。[结论]抗支清肺汤治疗支原体肺炎有较好的疗效,它可调节T细胞亚群比例,使紊乱的免疫功能得以恢复而促进机体康复。

[Objective]To observe the curative effect of Kangzhiqingfeitang for mycoplasmal pneumonia in children by improving the signs of patients and investigate the machanism of the treatment by analyzing the results of celluler immunity, [Methods] 120 cases with mycoplasmal pneumonia were allocated to 2 groups randomly. The treatment group（60 cases）by Kangzhiqingfeitang and the control group（60 cases）was treated by azithromycin. [Results]The total effective rates were 90% and 81.7 % in treatment and control group respectlvely（P〈0. 01）. The Kangzhiqingfeitang was more effective than azithromycin in elimilating fever and inhibiting cough,etc, The level of CD4 was significantly changed（P〈0.05）after treatment in treatment group, so were the level of CD4 and CD4/CD8 （P〈0. 01）, The level of CD4 , CD8 and CD4/CD8 was not significantly changed（P〉0.05）after treatment in control group. [Conclusion]Kangzhiqingfeitang possesses a good curative effect for mycoplasmal pneumonia in children. It can regulate the propor tion of T cell subset to recover the disorder function of patients.