摘要
采用手性选择体涂敷薄层色谱方法,拆分了盐酸普萘洛尔对映体,考察了β-环糊精、羟丙基-β-环糊精以及(2R,3R)-酒石酸-二-烷基酯等多种手性选择体拆分效果,得到手性选择体涂敷薄层色谱拆分盐酸普萘洛尔对映体最佳条件:采用β-环糊精、羟丙基-β-环糊精涂敷薄层色谱,以乙腈-仲丁醇混合溶剂作展开剂,展开剂中乙腈体积分数大于30%时,室温下展开均可拆分盐酸普萘洛尔对映体,并实现基线分离。实验同时发现,采用(2R,3R)-酒石酸-二-烷基酯涂敷薄层色谱拆分不能实现拆分。通过比较手性选择体结构,探讨了拆分机理。
Resolution of propranolol hydrochloride using chiral selectors impregnated thin-layer chromatography, chiral selectors such as β-cyclodextrin, hydroxypropyl-β-cyclodextrin and （2R, 3R）-di-alkyl tartrate were investigated. The optimal conditions of resolution were determined. It was found that resolution couldn＇t be achieved using （2R, 3R）-dialkyl tartrate impregnated thin-layer chromatography, resolution could only be carried out using β-cyclodextrin or hydroxypropyl-β-cyclodextrin impregnated thin - layer chromatography. The mechanism of resolution was discussed by comparing the chemical structures of the chiral selectors, and at the same time some useful conclusions were gained.
出处
《分析试验室》
CAS
CSCD
北大核心
2006年第2期59-62,共4页
Chinese Journal of Analysis Laboratory
基金
国家自然科学基金资助项目(20376085)
中南大学研究生教育创新选项立项项目(040206)
关键词
手性选择体
涂敷
薄层色谱
拆分
盐酸普萘洛尔
Chiral selectors
Impregnated
Thin-layer chromatography
Resolution
Propranolol hydrochloride
