摘要
目的建立HPLC法测定感冒安片中对乙酰氨基酚含量的方法。方法采用Hypersil ODS C18色谱枉(4·6min×250.0mm,5μ)由甲醇-4%甲琏溶液为流动相.流速为0.9mL·min^-1.检测波长为249nm。时乙酰氨基酚线性范围为0.20175~1.2105μg·平均回收率-99.21%.RSD=0.53%。结论谊方法简便、可靠、准确,可用于谊制剂的质量控制。
OBJECTIVE To establish a method of HPLC for determination of paraeetamol in Ganmaoan Tablets. METHODS Hypersil C18(4.6mm× 250mm,5μm) column was used. The methanol--4% formic acid solution was used as the mobile phase. The flow rate was 0.9mL · min^-1, The detection wavelength was set as 249nm. RESULTS For paracetamol,the linear range was 0. 20175-1. 2105μg,and the average recovery rate was 99.21% with RSD=0. 53%. CONCLUSION The method is simple,reliable,accurate and can be applied to the quality control of preparation.
出处
《海峡药学》
2006年第1期75-76,共2页
Strait Pharmaceutical Journal