唑来膦酸治疗恶性肿瘤骨转移疼痛临床观察

Clinical Study on Zoledronate for Treatment Pain of Cancer Bone Metastasis

目的：评价注射用唑来膦酸治疗恶性肿瘤骨转移疼痛的疗效和安全性。方法：54例患者随机分为治疗组和对照组：治疗组（28例）用唑来膦酸4mg加入生理盐水50ml静滴30min，对照组（26例）用氯屈膦酸二钠针剂（洛屈）300mg，溶于500ml生理盐水中，缓慢静滴3-4h连用5d。结果：治疗组镇痛有效率为75．00％，活动能力改善有效率为78．57％；对照组镇痛有效率69．23％，活动能力改善有效率76．92％，经统计学处理，两者疗效无显著性差异（P〉0．05）。唑来膦酸不良反应较少，患者耐受性好。结论：唑来膦酸是新一代骨吸收抑制剂，对恶性肿瘤骨转移所致疼痛有较好的止痛效果，且临床应用方便，安全性高。

Objective： To observe and evaluate the efficacy and safety of zoledronate to the pain of patients with bone metastases. Methods： Fifty four patients were randomly divided into two groups （A and B）. Group A （ the experimental group, 28 cases） was treated with zoledronate 4 mg ＋ NS 50 ml, intravenously; Group B （ the control group, 26 cases） was treated with domestic clodronate disodium 300 mg ＋ NS 500 ml,intravenously, for five days. Results： The effective rate of zoledronate was 75.00% with 78.57% improvement of physical movement, while in the Clodronate disodium group they wrer 69. 23% and 76.92% respectively. No statistical difference was revealed between the two groups. The main side effects were more painful temporarily, fever, nausea, and vomiting. Conclusion： Zoledronate can release pain of cancer bone metastasis, and it was conveniently to be used and safety.