阿尔茨海默病及血管性痴呆患者血清胆固醇、IL-6和V itB_(12)等水平的临床观测

Observation of Serum Cholesterol, IL-6 and VitB_(12) Levels in Alzheimer's Disease or Vascular Dementia Patients

目的:观测阿尔茨海默病(AD)及血管性痴呆(VD)患者血清胆固醇、白细胞介素6(IL-6)和维生素B12(V itB12)等水平的异同。方法:利用酶法进行血脂分析;采用双抗体夹心酶联免疫法(ELISA)测定血清白细胞介素6(IL-6)、白细胞介素10(IL-10)和肿瘤坏死因子α(TNFα)含量;电化学发光法检测V itB12及叶酸水平。结果:AD和VD组血清总胆固醇(T-Ch)、低密度脂蛋白胆固醇(LDL-C)及甘油三酯(TG)水平均显著高于正常对照组;AD组IL-6及TNFα明显高于VD组和正常对照组;VD组叶酸水平明显降低。结论:血脂升高可能同为AD及VD的病理生理基础,AD同时伴有明显炎症反应,叶酸水平降低为VD的另一病理特征。

Objective： To find the difference between Alzheimer＇s disease and vascular dementia patients in levels of serum cholesterol, interleukine-6 （ IL-6 ） and vitamin B12 （Vit B12 ）. Methods： Serum cholesterol was detected with enzyme assay, interleukines was detected with ELISA, Vit B12 and the folic acid was detected with electrochemical luminescence （ECL） assay. Results： The levels of serum T-Ch, LDL-C and TG in AD or VD patients were significantly higher than the levels in normal people. AD patients＇ IL-6 and TNFα were higher than VD patients or normal people. The folic acid levels in VD patients was low. Conclusion： AD or VD patients have a high level of serum cholesterol may be their common phys- iologic basis. Besides, AD patient had inflammatory reaction and VD patient had a low level of folic acid.