双氯芬酸钠明胶微球的制备及体内外释药的研究

Preparation of diclofenac sodium gelatin microspheres and its drug-release effect in Vitro and in Vivo

目的将双氯芬酸钠制备成明胶微球,考察其缓释效果。方法采用单凝聚法制备双氯芬酸钠明胶微球,并对微球的体内外释药进行考察。结果制备的微球粒径范围为48～100μm,平均粒径为70.70±11.29μm,载药量为35%。体内外释药实验结果表明双氯芬酸钠明胶微球有缓释作用。结论本法制备的双氯芬酸钠明胶微球能够起到明显缓释作用。

Objective To prepare diclofenac sodium gelatin microspheres and study the sustained-release effect. Methods Gelatin microspheres containing diclofenac sodium were prepared by simple coacervation technique and the drug release in vitro and vivo were tested. Results The diameter of the Gelatin microspheres was in the range of 48～100μm ,and the average diameter was 70.70～11.29μm, and the drug loading was 35%. These studies indicated Gelatin microspheres had obviously sustained-release effect in vitro and vivo. Conclusion The studies showed that the purpose of sustained release was achieved.