低剂量辛伐他汀对急性冠状动脉综合征患者血脂、C-反应蛋白及纤维蛋白原的影响

Effects of low dose simvastatin on the levels of plasma lipids,C-reactive protein and fibrinogen in patients with acute coronary syndrome

目的观察低剂量辛伐他汀治疗前后急性冠状动脉综合征(ACS)患者血脂、C-反应蛋白(CRP)及纤维蛋白原(FIB)的变化。方法120例ACS患者被随机分为治疗组和对照组,每组60例;对照组予常规治疗,治疗组在常规治疗基础上每日加用辛伐他汀20 mg,疗程2月。结果治疗组总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)较治疗前明显降低(P<0.05),高密度脂蛋白F胆固醇(HDL-C)较治疗前明显升高(P<0.05),CRP及纤维蛋白原较治疗前明显降低(P<0.05);对照组各观察指标治疗前后无明显变化(P>0.05)。结论低剂量辛伐他汀能有效调节急性冠状动脉综合征患者血浆中血脂、降低CRP及FIB水平,值得临床推广应用。

Objective To observe the changes of plasma lipid, C-reactive protein （CRP） and fibrinogen （FIB） in patients with acute coronary syndrome（ACS） treated with low dose simvastatin. Methods One hundred and twenty patients with ACS were randomly divided into treatment group and control group with 60 cases in each. The patients in the control group were treated with conventional therapy, and those in the treatment group were treated with 20 nag simvastatin per day at the base of control group. The course of treatment was 2 months. Results In the treatment group, the levels of total cholesterol （TC）, triglyceride （ TG）, low density lipoprotein cholesterol （ LDL-C ） , CRP and FIB were decreased significantly and the level of high-density lipoprotein cholesterol （HDL-C） was increased after the treatment （ all P 〈 0. 05）. There was not significant difference on these indexes between before and after treatment in the control group （ all P 〉 0. 05 ）. Conclusion The levels of plasma lipid, CRP and FIB can be effectively regulated with the treatment of low dose simvastatin in patients with ACS.