草酸铂联合氟尿嘧啶和亚叶酸钙治疗晚期胃癌

Oxaliplatin in Combination with Leucovorin and 5-Fluorouracil for Advanced Gastric Cancer

目的观察草酸铂(L-OHP)联合氟尿嘧啶(5-Fu)和亚叶酸钙(CF)治疗晚期胃癌的疗效及毒副反应。方法第1天采用L-OHP130mg/m2静脉滴注3h,CF200mg静脉滴注2h后,5-Fu500mg快速静脉注射后再用5-Fu2.4g/m2持续静脉滴注泵连续滴注46h,每3周重复,完成3周期后评价疗效,有效病例4周后确认。结果全组46例晚期胃癌患者,CR3例,PR20例,有效率(CR+PR)50%,中位疾病进展时间(TTP)5.7月,中位生存期10.5月。主要不良反应为轻度感觉神经毒性、恶心呕吐及骨髓抑制。结论草酸铂联合氟尿嘧啶和亚叶酸钙治疗晚期胃癌疗效较好,不良反应轻,可耐受。

Objective To evaluate the effects and adverse reactions of oxaliplatin（OXA） in combination with leucovorin （CF）and 5-fluorouracil（5-Fu） regimen for patients with advanced gastric cancer. Methods OXA 130mg/m^2 iv 3h dl ,CF 200mg iv 2h followed by 5-Fu 500mg iv plus 5-Fu 2. 4g/m^2 continuous infusion 46 hours, repeated every 3 weeks. Tumor assessment was done after 3 cycles and the effective cases were confirmed after 4 weeks. Results Among 46 patients with advanced gastric cancer, 3 patients reached complete response（CR）, 20 partial response （PR）. The overall response rate （CR ＋ PR） was 50%. The median progression free survival was 5.7 months. The median survival of all patients was 10. 5 months. The major adverse effect was mild neuro-sensory toxicity, nausea/vomiting and myelosuppression. Conclusion Oxaliplatin in Combination with leucovorin and 5 - fluorouracil shows good efficacy in treatment advanced gastric cancer. The toxicity is mild and tolerate.