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AM-36对鼠液压颅脑伤神经保护作用的初步研究 被引量：3

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摘要 AM-36是一种新型的电压依赖和应用依赖型Na^＋通道阻滞剂，有作者在脑缺血性卒中的动物模型中证实AM-36具有明确的神经保护作用，本研究首次在颅脑外伤（TBI）动物模型中使用AM-36，对这种新型的Na^＋通道阻滞剂在TBI中的神经保护作用进行初步研究。
作者 毛青 陆兆丰 Callaway Jennifer 丁勇 孙伟 梁玉敏 罗其中 江基尧
机构地区 上海市浦东新区浦南医院 上海仁济医院 澳大利亚墨尔本大学Howard Florey研究所
出处 《中华神经外科杂志》 CSCD 北大核心 2006年第2期89-92,共4页 Chinese Journal of Neurosurgery
关键词 神经保护作用 步研究 液压颅脑伤 通道阻滞剂 脑缺血性卒中 NA^+ 动物模型 电压依赖 颅脑外伤 鼠
分类号 R651.15 [医药卫生—外科学]
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参考文献15

  • 1Callaway JK. Investigation of AM-36: A novel neuroprotective agent. Clin and Exp Pharm and Physio,2001,28:913-918.
  • 2Callaway JK, Lawrence AJ, Jarrott B. AM-36,a novel neuroprotective agent, profoundly reduces reactive oxygen species formation and dopamine release in the striatum of conscious rats after endothelin-1-induced middle cerebral artery occlusion. Neuropharmacology, 2003, 44: 787-800.
  • 3Callaway JK, Castillo-Melendez M, Giardian SF, et al. Sodium channel blocking activity of AM-36 and sipatrigine (BW619C89):in vitro and in vivo evidence. Neuropharmacology, 2004, 47:146-155.
  • 4Callaway JK, Knight MJ, Watkins DJ, et al. Delayed treatment with AM-36, a novel neuroprotective agent, reduces neuronal damage after endothelin-1-induced middle cerebral artery occlusion in conscious rats. Stroke, 1999, 30: 2704-2712.
  • 5Maas AI, Dearden M, Servadei F, et al. Current recommendations for neurotrauma. Current Opinion in Critical Care, 2000, 6:281-292.
  • 6Marshall LF. Head injury: Recent past, present, and future.Neurosurgery, 2000, 47: 546-561.
  • 7Bullock R, Zauner A, Woodward JJ, et al. Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg, 1998, 89: 507-518.
  • 8Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Rev, 2002, 39: 55-73.
  • 9Taylor CP, Meldrum BS. Sodium channels as targets for neuroprotective drugs. Trends in Pharmacological Sciences, 1995,16: 309-316.
  • 10Bonoczk P, Gulyas B, Adam-Vizi V, et al. Role of sodium channel inhibition in neuroprotection: effect of vinpocetine.Brain Res Bull, 2000, 53: 245-254.

二级参考文献27

  • 1Melena J, Chidlow G, Osborne NN. Blockade of voltage-sensitive Na^+ channels by the 5 - HT1A receptor agonlst 8 - OH - DPAT:possible significance for neuroprotection. Eur. J. Pharmacol. 2000,406(3) :319 - 324.
  • 2Kline AE, Yu J, Massucci JL, et ill. Protective effects of the 5-HTIA receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rots. Neurosci Lett. 2002 ,333(3): 179- 182.
  • 3Nelson RM, Lambert DG, Richard GA, et al. Pharmacoloty of ischemia-induced glutamate efflux from rat cerebral cortex in vitro. Brain Res.2003,964(1):1 -8.
  • 4Chatton JY, Shimamoto K, Magistretti PJ. Effects of glial glutamate transporter inhibitors on intracellular Na^+ in mouse astrocytes. Brain Res, 2001,893(1-2) :46 - 52.
  • 5Ravens U, Himmel HM . Drugs preventing Na^+ and Ca^2+ overload. Pharmacol Res. 1999 ,39(3) : 167 - 174.
  • 6Tanaka K, Ito D, Suzuki S, et al. A novel voltage-sensitive Na+ and Ca2+ channel blocker, NS- 7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat. Brain Res. 2002,924(1):98-108.
  • 7Wolf J, Stys PK., Lusardi T, et al. Traumatic axonal injury induces calcium influx modulated by tetrodotoxin - sensitive sodium channels. J Neuroscience. 2001, 21(6) :1923 - 1930.
  • 8Stys PK. White matter injury mechanisms. Curr Mol Med. 2004 , 4 (2):113-130.
  • 9Callaway JK, Castillo- Melendez M, Giardina SF, et al. Sodium channel blocking activity of AM - 36 and 8ipatrigine (BW619C89) : in vitro and in vivo evidence. Neuropharmacology. 2004,47(1) : 146-155.
  • 10Taylor CP, Meldrum BS. Sodium channels as targets for neuropretective drugs. Trends in Pharmacological Sciences. 1995,16(9) :309 - 316.

共引文献26

同被引文献64

引证文献3

二级引证文献3

中华神经外科杂志
2006年 第2期

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