口服磁共振造影剂枸橼酸铁铵的临床应用

Clinical application of on oral MR contrast agent ferric ammonium citrate

目的探讨枸橼酸铁铵(ferric ammonium citrate,FAC)作为一种口服阴性造影剂在改善磁共振图像质量的应用。方法共收集患者50例,其中20例磁共振胰胆管水成像(MRCP),20例泌尿系统水成像(MRU),10例为盆腔成像。口服枸橼酸铁铵(3 g:600 mg/包)前、后以相同采集参数行磁共振成像,均采用GE 1.5 T磁共振机。并对口服枸橼酸铁铵前、后的图像质量进行比较。结果口服枸橼酸铁铵15 min后行MRCP成像,可有效消除胃、十二指肠内液体对图像的干扰。40 min到1h左右内分2次口服枸橼酸铁铵后行MRU和盆腔成像,可消除部分空肠、回肠、结肠内液体对图像的干扰。结论枸橼酸铁铵作为一种口服阴性造影剂开始逐步应用于临床工作中,可以改善MRCP、MRU及盆腔的图像质量。

Objective To investigate the efficiency of oral ferric ammonium citrate （FAC） as a negative gastrointestinal contrast agent in magnetic resonance imaging. Methods Altogether 50 patients were selected. MRCPwas performed for twenty patients; MRU, for twenty patients; and pelvic MR, for ten patients. Image assessment was based on the difference between non-oral FAC and oral FAC by same parameters. Results MRCP performed 15 minutes after oral FAC could delete effectively interference of liquid in the stomach and duodenum. MRU and pelvic MR performed 40 minutes after oral FAC could delete effectively interference of liquid in the jejunum, ileum and colon. Conclusion The clinical application of oral ferric ammonium citrate as a negative gastrointestinal contrast agent can improve image quality significantly in MRCP, MRU and pelvic MR.