放置VCu200　IUD不同年限宫颈粘液含铜量

Level of Copper Ion in Cervical Mucus of Various Years with VCu200IUD

本文用无火焰原子吸收分光光度仪ＨＩＴＡＣＨＩ－１８０测试置ＶＣｕ２００ＩＵＤ妇女宫颈粘液含铜量２６７例。其结果为自第１年平均含铜量２．６６±０．５８μｇ／ｇ粘液湿重至第１５年降为０．９１±０．６μｇ／ｇ粘液湿重，显示宫颈粘液含铜量随放置时间延长而渐减少。金属圆环组２１４例，各不同年限宫颈粘液含铜量平均为０．３５±０．０８～０．５６±０．１４μｇ／ｇ粘液湿重。未带器组２１例宫颈粘液平均含铜量为０．４７±０．１１μｇ／ｇ粘液湿重，ＶＣｕ２００组与金属圆环组各年限相比均有显著差异（Ｐ＜０．０５～０．００１）。与未带器组比各年ｆＫ亦皆有显著差异（Ｐ＜０．０５～０．００１）。文献报道铜离子浓度达１．０μｇ／ｍｌ有杀死或抑制精子活动的作用，浓度为０．７μｇ／ｍｌ能使孕卵胚泡中毒。本文置ＶＣｕ１２００ＩＵＤ者第１０年时铜离子含量为１．１１μｇ／ｇ粘液湿重，第１５年为０．９１±０．１μｇ／ｇ粘液湿重，依此推测ＶＣｕ２００ＩＵＤ至少可放置１０年以上。

The purpose of the study was to test the effective period of VCu200IUD.The concentration Of copper ion was measured by non flame atomic absorption spectrophotometer HITACHI-180.The average concentration of copper ion was 2.66±0. 58μg/g.w.win the first year,then gradually decreasing to 0. 91±0. 16μg/g.W.W fifteenth year in the group of VCu200IUD.There was average 0. 35±0. 08～0. 56±0. 14μg/g.w.w on the stainless steel ring group and 0.47±0. 11μ/g. w. w. for the control group. It is shownthat the concentration of copper ion on VCu200 IUD group was decreasing with the passage of time and there was a statistically significant difference between VCu200 IUD group,on the one hand and the stainless steel ring and the control groups,on the other hand(P<0. 05～0.001).No difference was found between the stainless steel ring and the control groups.According to literature, the concentration of copper ion attained1.0 μg/ml which was responsible for antlfertility.In the study COncentration 0f copper ion was higher that 1.0μg/ml in tenth year,which suggested effective period was over ten years.