脑梗死后抑郁与负性生活事件的关系及其抗抑郁治疗的研究

Study of relationship between post-cerebral infarction depression and negative life events and therapy of depression

目的探讨脑梗死后抑郁与负性生活事件的关系及其抗抑郁治疗的效果。方法将162例脑梗死患者按是否受负性生活事件影响分为负性生活事件影响组(A组,85例)和无负性生活事件影响组(B组,77例);采用Zung抑郁量表(SDS)及汉米尔顿抑郁量表(HRSD)进行抑郁症筛查,并对两组进行对比分析;对确诊为脑梗死后抑郁症患者每日早晨服百忧解20mg,连续用药4周,观察其疗效。结果A、B两组抑郁的发生率分别为56·5%、36·4%,两组比较差异显著(P<0·05);百忧解治疗脑梗死后抑郁的总有效率为59·9%。结论脑梗死后抑郁的发生与负性生活事件相关;应用百忧解治疗脑梗死后抑郁有效。

Objective To investigate the relationship between post-cerebral infarction depression and negative life events and the therapeutic effect on depression. Methods 162 patients with cerebral infarction were assigned to negative life event affecting group （A group,85） and non- negative life event affecting group （B group,77）, and then assessed condition of depression by self-rating depression scale （ SDS ） and Hamilton rating scale （HRSD）. The curative effect before and after therapy of fluoxetine （20 mg/d × 4 w） was compared. Results The incidence of depression are 56.5% in group A and 36.4% in group B respectively. The difference is significantly （ P 〈 0. 05 ）. The effective rate of Fluoxetine is 59.9% for post-cerebral infarction depression. Conclusions The incidence of post-cerebral infarction depression is related to negative life events. Fluoxetine is valid to treating post-cerebral infarction depression.