膀胱癌中Fas、FasL、Bcl-2及Bax的表达及意义

Expression and significance of Fas,FasL,Bcl-2 and Bax in bladder cancer

目的探讨凋亡调节基因Fas、FasL、Bcl-2及Bax在膀胱移行细胞癌中的表达及其与膀胱癌发生、发展和预后之间的关系。方法采用免疫组化染色法检测40例膀胱移行细胞癌、24例正常膀胱组织中Fas、FasL、Bcl-2及Bax的表达。结果Fas表达于正常组织和膀胱癌组织中,FasL、Bcl-2及Bax仅表达于膀胱癌组织中;Fas的表达与膀胱癌病理分级负相关,FasL、Bcl-2的表达与膀胱癌病理分级正相关;Fas、Bax在初发膀胱癌组织中的表达大于复发膀胱癌。结论Fas、FasL、Bcl-2及Bax的表达,可能与膀胱癌细胞的凋亡及免疫逃避等密切相关,影响膀胱癌的发生、发展和预后。

Objective To investigate the relationship between the expression of Fas, FasL, Bcl-2 and Bax in transitional cell carcinoma of bladder and its clinical significance. Methods Immunohistochemistry method was used to detect the expression of Fas, FasL, Bcl-2 and Bax in 40 specimens of transitional cell carcinoma of bladder and 24 specimens of normal bladder mucosa tissue. Results The positive expression of Fas was detected both in transitional cell carcinonma of bladder and in normal bladder mucosa tissue, while FasL, Bcl-2 and Bax only in transitional cell carcinonma of bladder. The expression of Fas was significantly lower in careinoma of high-grade malignancy than in carcinoma of low-grade malignancy （P〈0. 05）, while the expression of FasL and Bcl-2 was significantly higner in high-grade carcinoma than in low-grade carcinoma （P〈0. 05）. The expression of Fas and Bax was significantly higher in nonrecurrent group than in recurrent group （P〈0. 05）. Conclusion The expression of Fas, FasL, Bcl-2 and Bax may play an important role in the process of apoptosis and immune evasion, and may be closely related to the pathogenesis and development of transitional cell carcinonma of bladder.