摘要
目的:检测生殖器疱疹患者的氧化应激状态,以探讨其与生殖器疱疹的关系。方法:本研究通过67例生殖器疱疹患者血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)和一氧化氮(NO)的水平来评估生殖器疱疹患者的氧化应激状态。结果:生殖器疱疹患者SOD及GSH-Px活力低于正常人,MDA及NO浓度高于正常人(P<0.05),且NO浓度与SOD活力呈负相关,与MDA浓度呈正相关(P<0.05)。结论:生殖器疱疹患者氧化应激失衡,表现为氧化水平升高,抗氧化能力下降。
Objective： To determine the level of oxidative stress in the patients with genital herpes （GH）. Methods：The activity of superoxide dismutase （SOD） and glutathione peroxidase （GSH- Px）, concentration of malonyl- dialdehyde （MDA） and nitric oxide （NO） were determined in sera of patients with GH. Results： SOD activity in the sera significantly decreased and MDA concentration significantly increased in patients than those in control group （ P 〈 0.05）. The activity of GSH- Px decreased while the concentration of NO increased in GH patients （P 〈 0.05）. In addition, the NO concentration was negatively correlated with the activity of SOD, and positively with the concentration of MDA （P 〈 0.05）. Conclusion： The patients with genital herpes were in the state of high oxidation and low anti - oxidation.
出处
《中国麻风皮肤病杂志》
2006年第2期117-118,共2页
China Journal of Leprosy and Skin Diseases
