醛固酮与慢性肾脏疾病的关系

Relationship of Aldosterone and Chronic Kidney Disease

醛固酮通过对血流动力学的影响以及直接细胞作用两种主要机制参与肾脏损伤。目前,阻断肾素-血管紧张素-醛固酮系统的药物不能完全阻断醛固酮的作用。新的醛固酮受体阻滞剂的出现,可能提供了延缓慢性肾脏疾病进展的新途径,但还有很多问题有待于解决。

Aldosterone contributes to renal injury through hemodynamic and direct cellular actions,which may not be completely blocked by the use of angiotensin converting enzyme inhibitor and angiotensin Ⅱ receptor blocker. Aldosterone antagonist offers additional benefits to retard the progression of chronic renal disease. Before its broad use, however, many questions have not been answered.