骨髓腔内注射造血干细胞移植的研究和应用进展

Progress of Research and Application on Hematopoietic Stem Cell Transplantation by Intra-bone Marrow Injection—Review

骨髓腔内注射造血干细胞移植旨在促进HSC的归巢。近年来已有大量的动物实验肯定了不同来源供体细胞通过骨髓腔内注射能有效地归巢并植入骨髓、迅速重建受体造血和免疫功能、减少GVHD,诱导同种异基因器官移植免疫耐受,提高受体生存率。本文主要对该技术在骨髓移植、脐血移植、研究HSC生物学特性等方面的作用以及临床应用前景进行综述。

The purpose of hematopoietic stem cell transplantation by intra-bone marrow injection （IBM-HSCT） is to facilitate the homing of HSC. It has been recently proven in many animal experiments that different kinds of donor cells could efficiently home and engraft into the bone marrow by IBM-HSCT, which led to the rapid hemopoietic and immune recovery of recipients,preventing the development of GVHD, inducing the donor-specific tolerance in allogeneic organ transplantation, and promoting the survival rate of recipients. In this review, the effect of IBM-BMT and IBM-UCBT, the application of IBM injection technique in the study on HSC＇ s biological characteristics, and its prospect for clinical HSCT were sumarized.