间充质干细胞在造血调控中的作用

Mesenchymal Stem Cells in Hematopoietic Regulation—Review

间充质干细胞(MSC)作为造血微环境主要细胞成分的来源,具有自我更新和多向分化的潜能,通过与造血细胞直接接触、分泌细胞外基质及多种细胞因子维持造血微环境结构和功能的完整性,进而实现对造血的精细调控。本文结合近几年来国内外MSC的研究进展,就MSC在造血调控中的作用,诸如MSC分泌多种支持造血的细胞因子,MSC表达与造血细胞相互作用的黏附分子,联合移植MSC对造血重建的支持作用及其临床应用前景作一综述。

As the progenitor of most cell components in the hematopoietic microenviroment, mesenchymal stem cells （MSC） exhibit self-renewal and multilineage differentiation capacity. Through direct interaction with hematopoietic cells, secreting extracellular matrix and factors, MSC maintain the integrity of hematopoietic microenvironment and regulate hematopoiesis accurately. This review summarized the function of MSC in hematopoietic regulation, such as secretion of cytokines supporting hematopoiesis, MSC expression and adhesion molecules interacting with hematopoietic cells, and supportive effects of transplantation combining MSC with HSC on hematopoietic reconstraction, and its clinical perspectives.