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Graves病患者血清可溶型TRAIL水平升高 被引量：2

Elevation of serum soluble TRAIL level in patients with Graves′ disease
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摘要 通过检测50例Graves病(GD)患者、22例原发性甲状腺功能减退症患者与40名健康人血清中可溶型肿瘤坏死因子相关凋亡诱导配体(sTRAIL),发现GD病患者sTRAIL水平明显升高,提示sTRAIL可能与其病理改变和免疫状态有关。 The serum level of soluble tumor necrosis factor-related apoptosis-inducing ligand （sTRAIL） in the patients with Graves＇ disease （GD） was significantly higher than that in healthy controls and patients with hypothyroidism, suggesting that sTRAIL may play an important role in the pathogenesis of GD,
作者 史治宙 姬秋和 宋朝君 汪静 金伯泉
机构地区 第四军医大学西京医院内分泌科 第四军医大学免疫学教研室 第四军医大学西京医院核医学科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2006年第1期55-56,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 格雷夫斯病 可溶型肿瘤坏死因子相关凋亡诱导配体 细胞凋亡 Graves＇ disease Soluble tumor-necrosis-factor-related apoptosis-inducing ligand Apoptosis
分类号 R581.1 [医药卫生—内分泌]
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共引文献34

同被引文献13

  • 1成诗银,张惠中,陈剑秋,张丽,韩明坤.肿瘤细胞内特异表达TRAIL载体的构建及其在喉癌细胞株Hepa2中的表达[J].第四军医大学学报,2005,26(12):1108-1111. 被引量：4
  • 2史轶蘩.协和内分泌和代谢学[M].北京:科学出版社,2000.1370.
  • 3Morrison B, Tang Z, Jacobs B, et al. Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-β-induced apoptosis in ovarian carcinoma. Biochem J, 2005,385 (Pt 2) : 595-603.
  • 4Hofbauer LC, Khosla S, Dunstan CR, et al. The roles of osteoprotegerin and osteoprotegerin ligand in the paraerine regulation of bone resorption. J Bone Miner Res, 2000,15:2-12.
  • 5Sanlioglu AD, Dirice E, Aydin C, et al. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Carleer, 2005,5 : 54.
  • 6Pritzker LB, Scatena M, Giaehelli CM. The Role of Osteoprotegerin and Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Human Microvascular Endothelial Cell Survival. Mol Biol cell, 2004, 15 (6) : 2834-2841.
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  • 8Morrison B，Tang Z，Jacobs B，et al．Apo2L／TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-β-induced apoptosis in ovarian carcinoma．Biochem J，2005，385(Pt 2)：595-603．
  • 9HoPoauer LC，Khosla S，Dunstan CR，et al．The roles of osteoprotegerin and osteoprolegerin ligand in the paraerine regulation of bone resorption．J Bone Miner Res，2000，15：2-12．
  • 10Sanlioglu AD，Difice E，Aydin C，et al．Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells．BMC Cancer．2005,5：54．

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中华内分泌代谢杂志
2006年 第1期

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