^(11)C-胆碱PET显像鉴别肺部病变性质及探查肺癌转移灶的价值

^(11)C-choline PET imaging for the identification of pulmonary lesions and detection of metastases

目的探讨^(11)C-胆碱 PET 显像对鉴别肺部病变性质和探查肺癌转移灶的价值。方法对33例肺部病变患者进行^(11)C-胆碱 PET 显像,用定性和半定量法进行分析,并与病理检查及随访结果进行比较.结果 24处病理检查证实为肺恶性病变的病灶均可见高胆碱浓聚,标准摄取值(SUV)为0.6～39.2(5.26±7.50)。10处肺良性病灶中除1处肺新型隐球菌感染外,余9处 PET 显像均为阴性。^(11)C-胆碱 PET 显像检出纵隔淋巴结转移12枚(12/15枚),远处转移病灶4处(4/6处)。结论^(11)C-胆碱 PET 显像是鉴别肺部病变性质和探查肺癌转移灶准确、可靠的方法。

Objective To evaluate ^11C-choline PET imaging for the identification of pulmonary lesions and detection of metastases. Methods ^11C-choline PET imaging was performed in 33 patients with pulmonary lesions. The results were compared with pathology and operation. Results ^11C-choline PET imaging demonstrated increased choline uptake in 24 histology-proved malignant lesions [ standardized uptake value （SUV） 0.6 - 39.2 （5.26 ± 7.50） ] , whereas no focal increased choline uptake was seen in 9 benign lesions except 1 with cryptococcosis . ^11C-choline PET imaging detected 12 mediastinal lymph node metastases （ 12/15 ） and 4 distant metastases （4/6）. Conclusion ^11C-choline PET imaging is a reliable and useful method for identification of pulmonary lesions and detection of metastases.