浸润性乳腺导管癌组织中Ezrin和钙粘素E的表达与淋巴结转移的关系

Expression of Ezrin and E-cadherin in Invasive Ductal Breast Cancer and Their Correlations to Lymphatic Metastasis

背景与目的:Ezrin是一种细胞骨架连接蛋白,参与调节肿瘤细胞的生长和转移。本研究通过检测Ezrin和钙粘素E(E-cadherin)在浸润性乳腺导管癌中的表达情况,探讨其在淋巴结转移中的意义。方法:采用免疫组织化学SP法检测60例浸润性乳腺导管癌病理组织切片中Ezrin和E-cadherin的表达。结果:Ezrin在37例无转移的癌组织中19例异常表达(51.35%),23例有转移的癌组织中17例异常表达(73.91%)。E-cadherin在无转移的癌组织中15例异常表达(40.54%),而在有转移的癌组织中15例异常表达(65.22%)。Ezrin异常表达与E-cadherin异常表达有显著的正相关性(r=0.898,P=0.038)。结论:Ezrin和E-cadherin与乳腺导管癌的浸润和转移密切相关,可以作为预测浸润性乳腺导管癌淋巴结转移的重要肿瘤标志物。

BACKGROUND ＆ OBJECTIVE： Ezrin, a cytoskeleton linker protein, is actively involved in regulating the growth and metastasis of cancer cells. This study was performed to detect the expression of Ezrin and E-cadherin in primary invasive ductal breast cancer in order to evaluate their possible roles in lymphatic metastasis. METHODS. The expression of Ezrin and E-cadherin in 60 specimens of primary invasive ductal breast cancer （23 with metastasis, 37 without metastasis） was detected by SP immunohistochemistry. RESULTS： The abnormal expression rates of Ezrin and E-cadherin were significantly higher in the cases with metastasis than in the cases without metastasis （73.91% vs. 51.35%, P=0.039; 65.22% vs. 40.54%, P〈0.001）. The abnormal expression of Ezrin was positively correlated to that of E-cadherin （r=0.898, P=0.036）. CONCLUSION： Ezrin and E-cadherin are closely related to invasion and metastasis of ductal breast cancer, suggesting that they are important tumor markers in predicting lymphatic metastasis of invasive ductal breast cancer.