果蝇蜕皮激素诱导程序性细胞死亡的遗传调控因子

Genetic regulators involved in ecdysone-induced programmed cell death in Drosophila

近年来关于果蝇程序性细胞死亡(programmedcelldeath,PCD)的研究结果表明,在果蝇的变态发育过程中,蜕皮激素与受体结合后诱导转录因子的表达。这些转录因子作为程序性细胞死亡调控网络中的初、次级应答信号,激活凋亡诱导因子Reaper、Hid和Grim的表达。Reaper、Hid和Grim进而阻止凋亡蛋白抑制因子的活性,从而启动半胱氨酸蛋白酶caspase途径,引起细胞凋亡(apoptosis)。该文综述了蜕皮激素诱导的果蝇程序性细胞死亡中各遗传调控因子之间的关系。

Recent reports on programmed cell death （PCD）（ or apoptosis） in Drosophila reveal that during metamorphosis, binding of ecdysone to the complex of ecdysone receptor and ultraspiracle results in expression of the transcription factors that are primarily and secondarily responsive to PCD signals in the regulatory networks. These transcription factors activate the expression of inducers （Reaper, Hid, and Grim） of apoptosis and the activated inducers suppress activity of inhibitors of apoptosis proteins, resulting in onset of the caspasedependent apoptosis. The genetic regulators that are involved in the ecdysone-induced programmed cell death and their relationship between each other were reviewed in this article