抗癌丝裂霉素白蛋白微球的制备及体外释药性能

Preparation and the Release Properties of Mitomycin Loaded Albumin Microspheres in Vitro

以人血清白蛋白为载体材料,精制棉籽油为油相,采用乳化热固法制备了抗癌丝裂霉素C白蛋白微球,对丝裂霉素C白蛋白微球的粒径、载药量、包封率以及药物的体外释药等特性进行了研究。结果表明,采用乳化热固法制备的白蛋白微球平均粒径为500 nm;丝裂霉素C白蛋白微球的平均载药量为2.98μg/m g,包封率为61.2%,在体外具有明显的药物缓释效果。

Mitomycin C albumin microspheres were prepared by emulsion-heat denaturation method using the natural macromolecule human serum albumin as core material and refined cottonseed oil as oil phase. Properties of mitomycin C albumin microspheres were investigated, including particle size, drug loading capacity, embedding ratio and drug sustained release property in vitro. The results show that the average size of spherical microspheres prepared by emulsion-heat denaturation method is about 500 nm; the average drug loading of mitomyein C albumin microspheres is about 2.98μg/mg and the sustained drug release effect is very obvious in vitro.