期刊文献+

微量元素铬的营养生物化学研究进展 被引量:9

Advances on Nutritional Biochemistry of Trace Element Chromium
下载PDF
导出
摘要 目的介绍微量元素铬的生物学功能及其在糖尿病治疗上的应用,安全性和毒性评价。方法通过查阅文献,对微量元素铬和糖尿病的关系及其在药理学和毒理学方面的研究进行阐述。结果与结论微量元素铬是胰岛素的一种“协同激素”,作为胰岛素增敏剂激活胰岛素受体上酪氨酸激酶的活性,增强胰岛素的功能。缺铬可以使糖耐量异常、β细胞敏感性降低及胰岛素受体减少而引起糖尿病。补充铬营养剂不仅可以降低糖尿病病人的血糖、改善胰岛素抵抗症状,而且可以降低血脂,并具有剂量依赖性。铬营养剂在糖尿病控制和预防中具有一定的辅助疗效,其安全性与铬化合物的配体结构有关。
作者 施秀芳
出处 《中国药学杂志》 CAS CSCD 北大核心 2006年第3期167-170,237,共5页 Chinese Pharmaceutical Journal
  • 相关文献

参考文献40

  • 1TRUMBO P,YATES A A,SCHLICKEK S,et al.Dietary references intakes:vitamin A,vitamin K,arsenic,boron,chromium,copper,iodine,iron,molybdenum,nickel,silicon,vanadium,and zinc[J].J Am Diet Assoc,2001,101:294-301.
  • 2MERTZ W,SCHWARZ K.Impaired intravenous glucose tolerance as an early sign of dietary necrotic liver degeneration[J].Arch Biochem Biophys,1955,58:504-506.
  • 3SCHWARZ K,MERTZ W.Chromium(Ⅲ) and the glucose tolerance factor[J].Arch Biochem Biophys,1959,85:292-295.
  • 4SUMRALL K H,VINCENT J B.Is glucose tolerance factor an artifact produced by acid hydrolysis of low-molecular-weight chromium-binding substance?[J].Polyhedron,1997,16(23):4171-4177.
  • 5CLODFELDER B J,UPCHURCH R G,VINCENT J B.A comparison of the insulin-sensitive transport of chromium in healthy and model diabetic rats[J].J Inorg Biochem,2004,98:522-525.
  • 6GHOSH D,BHATTACHARYA B,MUKHERJEE B,et al.Role of chromium supplementation in indians with type 2 diabetes mellitus[J].J Nutr Biochem,2002,13:690-697.
  • 7MORRIS B W,MACNEIL S,HARDISTY C A,et al.Chromium homeostasis in patients with type Ⅱ (NIDDM) diabetes[J].J Trace Elem Med Biol,1999,13:57-61.
  • 8DING W J,CHAI Z F,FENG W Y,et al.Determination of chromium in serum and urine for healthy men and diabetic patients by graphite furnace atomic absorption spectrometry[J].Guangdong Trace Elem Sci (广东微量元素科学),1997,4(11):44-46.
  • 9ZHANGMR HUBY HEQ etal.Study on the relationship of content of serum chromium and diabetes[J].微量元素与健康研究,2002,19(1):20-24.
  • 10WILD S,ROGLIC G,GREEN A,et al.Global prevalence of diabetes:estimates for the year 2000 and projections for 2030[J].Diabetes Care,2004,27(5):1047-1053.

二级参考文献27

  • 1张林,石蕾.微量元素铬在治疗糖尿病中的临床应用[J].国外医学(医学地理分册),1996,17(4):161-162. 被引量:4
  • 2[2]Schwarz K, Mertz W. Chrommium( Ⅲ ) and glucose tolerance factor [J]. Arch Biochem Biophys, 1959,85 ( 1 ): 292.
  • 3[3]Evans GW, Ropginksi EE, Mertz W. Interaction of the glucose tolerance factor (GTF) with insulin [ J ] . Biochem Biophs Res Commun ,1973,50(3) :718.
  • 4[4]Mirsky N, Weiss A, Dori Z. Chromium in biological systems, I. Some observations on glucose tolerance factor in yeast[ J]. J Inorg Biochem,1980,13(1):11.
  • 5[5]Guan XF, Matte JJ, Ku KP, et al. High chromium yeast supplementation improves glucose tolerance in pigs by decreasing hepatic extraction of insulin [J]. Nutri,2000(5); 130:1274.
  • 6[7]Gonzalez-Vergara E, Hegenauer J, Saltman P, et al. Synthesis and structure of a trinuclear chromium(Ⅲ)-nicotinic acid complex [J]. Inorg Chim Acta, 1982,66(6): 115.
  • 7[8]Chang JC, Gerdom LE, Bzenziger NC, et al. Synthesis and molecular structure of carboxylbound nicotinic acid (niacin) complexes of chromium( Ⅲ ) [J]. Inorg Chem, 1983,22(12): 1739.
  • 8[9]Cooper JA, Anderson BF, Buckley PD, et al. Structure and biological activity of nitrogen and oxygen coordinated nicotinic acid complexes of chromium[J]. Inorg Chim Acta, 1984,91 ( 1 ): 1.
  • 9[10]Kegley EB, Spears JW. Immune response, glucose metabolism, and performance of stressed feeder calves fed inorganic or organic chromium[J].AnimSci, 1995,73(9): 2721.
  • 10[13]Preuss HG, Wallerstedt D, Talpur N, et al. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study [ J ]. Med, 2000,31 (5-6) :227.

共引文献7

同被引文献167

引证文献9

二级引证文献41

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部