C-反应蛋白在川崎病诊疗中的意义

The significance of C-reactive protein in the diagnosis and therapy of Kawasaki Disease

目的：探讨C反应蛋白（CRP）在川崎病（KD）诊疗中的意义。方法：30例KD患儿采用丙种球蛋白、肠溶阿司匹林、潘生丁等药物进行治疗，观察治疗前后患儿的CRP、血小板（PLT）、白细胞（WBC）的变化。结果：治疗后患儿血清CRP含量、WBC总数较治疗前明显下降，差异有统计学意义（P〈0．05～0．01），PLT计数无明显变化（P〉0．05）。结论：KD早期血清CRP含量升高，治疗3～5d内CRP含量迅速下降，与临床症状的恢复成正比，CRP对KD的诊疗有一定临床指导意义。

Objective： To investigate increase of C- reactive protein （CRP） in the early stage of Kawasaki Disease （KD） and its response to therapy. Methods： Thirty pediatric inpatients were selected, who suffered from Kawasaki Disease. The quantity of CRP was determined in the early of this disease, and the recovery of CRP was observed after standard therapy. Results： The quantity of CRP of all the thirty pediatric patients suffering from Kawasaki Disease increased in the early, but it decreased rapidly or returned to the normal level in three to five days after standard therapy of drugs, such as immunlglobulin, enteric coated aspirin, persantine and so on. Conclusions： Although the increase of CRP in the early stage of this disease was no specificity, the rapid decrease of CRP, which occurred in three to five days after standard therapy, was positively proportional to the recovery of clinical symptom. CRP has certain instructive significance in clinical practice when it is used for observing the response to therapy and judging the prognosis of KD.