生姜提取物对X射线致小鼠红细胞损伤的保护作用

Protective Effects of Ginger Extract on RBC of X-Ray Irradiated Mice

目的观察生姜提取物对X射线致小鼠外周血细胞损伤的保护作用。方法选择昆明种小鼠100只,随机分为5组(1个未照射组,1个单纯照射组,3个生姜提取物暴露组),雌雄各半,3个生姜提取物暴露组分别在照射前给予不同剂量生姜提取物(9.3、4.7、2.3ml/kg)灌胃,非照射组和单纯照射组分别以相同体积的玉米油灌胃。X射线照射的剂量为2Gy,照射2次,间隔24h,末次照射后48h,分别测定血中红细胞计数(RBC)、血红蛋白含量(HCB)、红细胞比积(HCT)、红细胞平均体积(MCV)、红细胞平均血红蛋白浓度(MCHC)、红细胞平均血红蛋白量(MCH)、红细胞体积分布宽度(RDW)。结果与未照射组比较,单纯照射组X射线暴露可引起雌、雄小鼠RBC、HCB、HCT减少,MCH、RDW增高,还可导致雌性小鼠MCHC的增高(P<0.05)。而与单纯照射组比较,4.7、2.3ml/kg生姜提取物组雌、雄小鼠RBC、HCB、HCT上升,RDW下降,,雌性小鼠MCH下降(P<0.05)。结论生姜提取物对X射线引起的小鼠RBC损伤具有保护作用。

Objective To study the protective effect of ginger extract on RBC of X-ray irradiated mice. Methods Mice were given extract of ginger with three doses, namely 9.3 ml/kg bw, 4.7 ml/kg bw and 2.3 ml/kg bw before X-ray irradiation（dose was 2.0 Gy, for two times, the interval was 24 h）, 48 hours after the last irradiation, the blood samples were collected and RBC, HCB, HCT, MCV, MCHC, MCH, RDW were examined. Results Compared with the exposed control, RBC, HCB, HCT increased and MCH, RDW decreased significantly in ginger treated groups. Conclusion The ginger extract has a certain effect to prevent RBC from damaging induced by X-ray irradiation in mice.