摘要
目的:研究DPC4(SMAD4)蛋白在胃癌的表达及临床意义。方法:应用免疫组化SP法,对40例胃癌及20例癌周粘膜进行检测,并结合临床资料进行研究。结果:胃癌DPC4(SMAD4)蛋白的表达阳性率为75%(30/40),20例癌周粘膜内DPC4(SMAD4)蛋白均呈强阳性表达,两者比较差异有显著性意义(P<0.05)。DPC4蛋白在胃癌的表达与患者年龄、发生部位无关(P>0.05),而与临床分期、淋巴结转移、病理分级、肿物大小有关性(P<0.01)。结论:DPC4(SMAD4)蛋白的表达与胃癌的发生发展密切相关,对预后的判断有参考价值。
Objective： To investigate the expression of DPC4 in gastric cancer and evaluate its clinical significance. Methods： DPC4 was measured in 80 cases of gastric cancer tissues and 20 cases of benign disease by immunohistochemistry SP method using monoclonal antibody to their protein. Results： The expression of DPC4 in breast cancer was 75% （30/40 ）. There was significantly higher than that in benign disease. Their expression was not related to gender and position of the disease （ P 〉 0.05 ）, but related to pathology stage clinical stage, lymph node metastasis and tumor sides （ P 〈 0.01 ）. Conclusion： The expression of DPC4 was closely correlated with the gastric cancer and more valuable about predicting.
出处
《河北医学》
CAS
2006年第2期111-113,共3页
Hebei Medicine
