潘托拉唑预防呼吸衰竭并上消化道出血疗效观察

The Effectiveness of Pantoprazole as a Preventive Approach to Stress Ulcer Caused by Respiratory Failure

目的：观察潘托拉唑预防呼吸衰竭并上消化道出血的疗效及安全性。方法：将92例呼吸衰竭患者随机分为治疗组和对照组，分别用潘托拉唑和雷尼替丁预防治疗，观察2组病人胃液的PH及有无上消化道出血的临床表现。结果：治疗组患者胃液的PH值明显高于对照组（t=9．67-18．67，P〈0．01），治疗组46例病人消化道出血的发生率为2．71％（1／46），对照组病人消化道出血发生率为13．04％（6／46），两组上消化道出血发生率比较有显著性差异（X2=4．46，P〈0．05）。结论：潘托拉唑能提高呼吸衰竭患者胃液中的PH值，预防上消化道出血的作用优于雷尼替丁。

Objective： To study the effectiveness of pantoprazole as a preventive approach to stress ulcer caused by respiratory failure. Method： 92 cases diagnosed with respiratory failure were divided into 2 groups randomly,The control group was treated with ranitidine while the therapy group with pantoprazole, respectively. Then the PH values of gastric juice in both groups were observed and all patients were investigated to determine the complication of stress ulcer. Result： The PH value in therapy group was higher than control group （ t =9.67 - 18.67 ,p 〈0.01 ）. The incidence rate of stress ulcer was 2.71% （ 1/46 ） ,in the studied group but that of control group was 13.04% （ 6/46 ）, which was significantly different （ X^2 = 4.46, p 〈 0.05 ）. Conclusion： Pantoprazole could increase the PH value of gastric juice in patients with respiratory failure and was r more effctive than ranitidine to the prevntion of stress ulcer caused by respiratory failure.