亚临床甲状腺功能减退患者血浆脂蛋白与左旋甲状腺素的关系探讨被引量：1

The Effects of Levothyroxine on Lipoprotein in Patients with Subclinical Hypothyroidism

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摘要目的:探讨左旋甲状腺素对亚临床甲状腺功能减退症(SH)患者血脂水平的影响。方法:把50例亚临床甲状腺功能减退患者(B组)与48名匹配健康者(A组)进行统计分析,治疗组服用左旋甲状腺素片。结果:经治疗后,这些患者的血浆脂蛋白(A)水平有治疗前的(252.1±79.4)MG/L下降至治疗后的(187.4±76.3)MG/L(P<0.05)。结论:在甲减状态下,血浆脂蛋白可以异常升高,而左旋甲状腺素变化与血浆脂蛋白水平变化呈负相关。 Objective： To study the effects of levothyroxine on lipoprotein in patients with subclinical hypothyroidism （ SH ）. Method： 50 patients with SH and 48 health men were performed statistical investigation, and the therapy group administrated levothyroxine. Result： After treatment, plasma lipoprotein （ a ）（ Lpa ） level was decreased administrated from （ 252. 1 ± 79.4 ） mg/L to （ 187.4 ± 76.3 ） mg/L （ P 〈 0.05 ） insuch patients. Conclusion： In the condition of SH, Lpa can be keep abnorbal high level, however, the alteration of levothyroxine ahd Lpa is negative correlation.

作者陈定宇叶林

机构地区广东省广州市第一人民医院内分泌科

出处《河北医学》 CAS 2006年第2期140-141,共2页 Hebei Medicine

关键词亚临床甲状腺功能减退症左旋甲状腺素脂蛋白 Subclinical hypothyroidism Levothyroxine Lipoprotein（ a）

分类号 R581.2 [医药卫生—内分泌]

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1Monzani F,Caraccio N,Kozakowa M,et al.Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism:a double-blind,placebo-controlled study [J].Clin Endocrinol Metab,2004,89(5):2099-2106.
2Jung CH,Sung KS,Shin HS,et al.Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile,hsCRP,and waist hip ratio in Korea [J].Korean Intern Med,2003 seo,18(3):146-153.
3Akbar DH,Ahmed MM,Hi jazi NA.Subclinical hypothyroidism in elderly women attending an outpatient clinic [J].Med Sci Monit,2004 May,10(5):CR229-232.
4Efstathiadou Z,Bitsis S,Milionis HJ,et al.Lipid profile in subclinical hypothyroidism:is L-Thyroxine substitution beneficial [J].Eru Endocrinol,2001 Dec,145(6):705-710.
5Meier C,Staub JJ,Roth CB,et al.TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism:a duble-blind,placebo-controlled trial)Basel Thyroid Study) [J].Clin Endocrinol Metab,2001,86(10):4860-4866.
6Tagliaferri M,Berselli ME,Calo G,et al.Subclinical hypothyroidism in obese patients:relation to resting energy expenditure,serum leptin,body composition,and lipid profile [J].Obes Res,2001 Mar,196-201.
7董晓林.亚临床甲状腺功能减退症的研究进展[J].国外医学（内科学分册）,2002,29(1):29-31. 被引量：12

二级参考文献24

1Bindels AJ, Westendorp RG, Frolich M, et al. [J].Clin Endocrinol(Oxf), 1999,50(2) :217-220.
2Benediktsson R, Toft AD. [J]. Postgrad Med J,1998, 74(878) :729-732.
3Madeddu G, Spanu A, Falchi A, et al. [J]. Rays,1999,24(2) :229-242.
4Tunbridge WMG, Evered DC, Hall R. [J]. Clin Endocrinol, 1997,7:481-493.
5Huber G, Mitrache C, Guglielmetti M, et al. [J].Schweiz Med Wochenschr, 1998, 128 (48): 1902-1905.
6Samuel MH. [J]. Thyroid, 1998,8(9):803-813.
7Hansen D, Bennedbaek FN, Hansen LK, et al. [J].Eur J Endocrinol, 1999, 140(6) :512-518.
8Klein RZ, Haddow JE, Faix JD, et al. [J]. Clin Endocrinol, 1991,35:41-46.
9Ross DS. Subclinical hypothyroidism. In: Braverman LE and Utiger RD eds. Werner and Ingbar's Tne Thyroid, a Fundamental and Clinical Text. [M]. 17th ed.Philadelphia-New York: Lippincott-Raven JP Publishers; 1996: 1010-1015.
10Michalopoulou G, Alevizaki M, Piperingos G, et al.[J]. Eur J Endocrinol, 1998,138(2): 141-145.