间断性鼻罩式BiPAP通气治疗COPD急性发作的疗效观察

Evaluation of the efficacy of the discontinuously and nasally BiPAP ventilation therapy in COPD with acute outbreak

目的:观察间断性使用鼻罩式气道双水平正压(Bi-Level positive airway pressure,BiPAP)通气在治疗慢性阻塞性肺病(COPD)急性发作致呼吸衰竭患者时的疗效。方法:48例入选患者随机分为例数相同的试验组和对照组,在常规性治疗相同的情况下,对试验组间断使用鼻罩式BiPAP通气(每日3次,每次3h),对照组只予持续低流量给氧,连续治疗3天后观察两组病人临床症状改善状况及血气分析指标并进行统计学比较分析。结果:试验组病例症状、体征及血气分析主要指标的改善在治疗后均明显好于治疗前,且好于治疗后的对照组。结论:间断使用鼻罩式BiPAP通气是治疗COPD急性发作患者的一种有效的无创辅助通气方法。

Objective：To observe the effect of the discontinuously,nasally bilevel positive airway pressure（BiPAP） ventilation actualized on the patients with respiratory failure due to chronic obstructive pulmonary disease（COPD） with acute outbreak. Methods： The selected 48 patients were divided equally into test group and control one by randomization. While the conventional therapy were same in both groups, the patients in test group were discontinuously and nasally treated with BiPAP ventilation （3 hours every time and 3 times everyday） ,but the patients in control group were only treated by comtinuous oxygen therapy with low flux.Three days latex, the patients in two groups were compared with each other in the symptoms,signs and the parameters of blood - gases analysis which were analysed in statistics. Results：The clinical symptoms and the main parameters in test group were improved better than before and better than treated control group. Conclusion：The discontinuously and nasally BiPAP ventilation was an effective,noninvasive method for treating COPD with acute outbreak.