摘要
以HIV病毒中的TATA为识别位点,设计并合成了由四个N-甲基吡咯环和两个脂肪族氨基酸组成的聚酰胺类DNA识别分子———PyPyPyPyβCONH(CH2)6NH2.合成采用片段偶合的手段,利用卤仿反应和DCC/HOBT偶合反应,合成了含4个芳香杂环的聚酰胺,而且将含有两个游离氨基的脂肪族己二胺成功地接到了链尾.并用核磁共振谱和质谱对该化合物进行了表征.
A DNA recognizing polyamides molecule, PyPyPyPyβDNH （CH2）6NH2 which contains four-rings of N-methylpyrrole and two amino acids moieties, was synthesized by the chloroform reaction and the DCC/HOBT coupling reaction, and an amino-group of 1, 6-Diaminohexane was successfully linked to the polyamide. The structure of the polyamide derivative was confirmed by NMR and MS spectra.
出处
《陕西师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2006年第1期60-62,66,共4页
Journal of Shaanxi Normal University：Natural Science Edition
基金
国家自然科学基金资助项目(39970169
29872001)
