摘要
应用聚合酶链反应-限制性片段长度多态性分析技术检测31例非乳头状肾细胞癌3p21杂合子丢失。结果显示:肾细胞癌中3p21杂合子率为38.7%,杂合子丢失率为66.7%。杂合子丢失阳性患者的5年存活率为25.0%,而杂合子丢失阴性和纯合子未丢失患者的5年存活率为65.2%,二者比较,差异有显著性(P<0.05)。提示3p21杂合子丢失可能与非乳头状肾细胞癌的演化及预后有关。
Polymerase chain reaction-restriction fragment lenghth polymorphisms(PCR-RELP)analytic technique to detect the loss of heterozygosity(LOH)of 3p21 was carried out in 31 cases of nonpapillary renal cell carcinoma(RCC).The rate of heterozygosity was 38.7% and the rate of LOH 66.7% in RCC. The 5-year survival rate was 25. 0% in LOH positive cases while it was 65.2% in the LOH negative cases and in those with no loss of homozygosity.The difference between the 2 groups was stastically significant(P<0.05).It was suggested that LOH of 3p21 might be related to the evolution and prognosis in nonpapillary RCC.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1996年第4期230-232,共3页
Chinese Journal of Urology
基金
中国博士后科学基金