一氧化氮介导犬电生理诱发的阴茎勃起

An experimental study of the mechanism of nitric oxide mediation in pelvic nerve-stimulated erection

应用电刺激犬盆神经诱发阴茎勃起的动物模型，观察海绵体腔内注入左旋硝基精氨酸（Ｌ－ＮＮＡ）、美蓝（ＭＢ）及阿托品对电生理性勃起的影响。结果显示，左旋硝基精氨酸及美蓝均能显著地抑制电生理的勃起效应，阿托品可部分地抑制这种效应。说明电刺激盆神经诱发的勃起由ＮＯ－ｃＧＭＰ径路介导，其中部分ＮＯ为胆碱能性来源，外源性ＮＯ（硝普钠）注入阴茎海绵体腔可诱发剂量依赖型勃起效应，提示外源性ＮＯ用于临床阳萎治疗的潜在价值。

Adult male dogs were subjected to direct electrical stimulation of the pelvic nerves to induce penile tumescence. Intracavernous injection of L-NNA and methyline blue might significantly inhibit the pelvic nerve-stimulated tumescence and the latter effect was partialy blocked by atropine。Intracavernous injection of the NO-releasing substance(SNP) resulted in similar tumescence. The results suggested that penile erection is mediated by the NO-cGMP pathway.