摘要
应用电刺激犬盆神经诱发阴茎勃起的动物模型,观察海绵体腔内注入左旋硝基精氨酸(L-NNA)、美蓝(MB)及阿托品对电生理性勃起的影响。结果显示,左旋硝基精氨酸及美蓝均能显著地抑制电生理的勃起效应,阿托品可部分地抑制这种效应。说明电刺激盆神经诱发的勃起由NO-cGMP径路介导,其中部分NO为胆碱能性来源,外源性NO(硝普钠)注入阴茎海绵体腔可诱发剂量依赖型勃起效应,提示外源性NO用于临床阳萎治疗的潜在价值。
Adult male dogs were subjected to direct electrical stimulation of the pelvic nerves to induce penile tumescence. Intracavernous injection of L-NNA and methyline blue might significantly inhibit the pelvic nerve-stimulated tumescence and the latter effect was partialy blocked by atropine。Intracavernous injection of the NO-releasing substance(SNP) resulted in similar tumescence. The results suggested that penile erection is mediated by the NO-cGMP pathway.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1996年第4期241-243,共3页
Chinese Journal of Urology