神经干细胞移植治疗脑卒中后遗症50例临床效果分析

Clinical analysis of neural stem cells for treatment of sequela in 50 stroke patients

目的:观察应用神经干细胞移植治疗改善脑卒中患者功能独立性的临床疗效。方法:选择2004-01/2005-06哈尔滨医科大学附属第二医院和北京武装警察部队总医院收治的脑卒中患者50例。男31例,女19例;平均55岁;末次发病至接受神经干细胞移植时间平均为3.4年。其中基底节病变39例,脑干病变3例,其他部位(丘脑、大脑半球)8例,累计多部位的病变6例。所有患者腰椎穿刺蛛网膜下腔植入神经干细胞,1次/周,共计3次。采用美国功能独立性评测评分对患者术前,术后6月进行评定。主要评价6个方面的能力:生活自理能力,括约肌控制能力,活动能力,行动能力,理解交流能力,社会认识能力。分值高表示功能独立性好。结果:50例患者全部进入结果分析。脑卒中患者干细胞移植后6个月功能独立性评分显著高于移植前(99.86±7.61,95.84±7.51,P<0.01)。结论:神经干细胞移植可以一定程度地改善脑卒中患者的后遗症,提高患者生活质量。

AIM： To observe the clinical curative effect of transplantation of neural stem cell for improving the function independence in patients with stroke. METHODS： We chose 50 patients with stroke who received the treatment in the Second Hospital Affiliated to Harbin Medical University and Genend Hospital of Chinese People＇s Armed Police Force from January 2004 to June 2005, There were 31 male and 19 female with the average of 55 years; The average time from the last seizure to receiving the therapy was 3,4 years, Among them, pathological change at basal ganglia was found in 39 cases , pathological change at brain stem in 3 cases, pathological change at thalamencephalon and cerebral hemisphere in 8 cases and pathological change at multiple parts in 6 cases. Neural stem cells were transplanted into all the patients through lumbar acupuncture at subaraehnoid space, once a week, 3 times in total, America Function Independence Scoring was used to evaluate self care, sphincter control ability, locomotor activity, motor ability, comprehension and communication ability and social perceptual ability before and 6 months after operation, The higher scores, the better functional independence, RESULTS： All the 50 patients entered the stage of result analysis, Functional independence scoring was significantly higher 6 months after transplantation of neural stem cells than before transplantation in patients with stroke （99.86±7.61,95.84±7.51, P 〈 0,01）, CONCLUSION： Transplantation of neural stern cells can improve the sequela of stroke to some extent and improve the living quality of patients with stroke, the NSCT is an effective way to treat the sequela of stroke,