乳腺癌中bag-1的表达及与腋窝淋巴结转移的关系

Expression of bag-1 and its correlation with axillary lymph node metastasis in breast cancer.

目的探讨乳腺癌组织中bag-1的表达及其与肿瘤细胞增殖和腋窝淋巴结转移的关系。方法收集100例乳腺癌,其中有腋窝淋巴结转移的58例。采用免疫组化SABC法检测bag-1的表达情况。结果bag-1在乳腺癌组织中阳性表达率为85.0%;在I、II、III期的乳腺癌中bag-1阳性表达率分别为87.5%,82.4%,88.2%,三者无明显差异(P>0.05);有腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为89.6%,无腋窝淋巴结转移的乳腺癌中bag-1阳性表达率为78.6%,无明显差异(P>0.05)。结论乳腺癌中bag-1高表达,其表达与肿瘤细胞增殖和腋窝淋巴结转移无关。

Objective To investigate the expression of bag - 1 gene and its correlation with axillary lymph node metastasis in breast cancer. Methods Expression of bag - 1 in 100 cases of breast cancer （58 cases with axillary lymph node metastasis ） were detected by SABC immunohistochemistry. Results The positive rate of bag - 1 expression in breast cancer was 85.0%. The bag - 1 expression rate among pathologic grades Ⅰ、Ⅱ、Ⅲ were 87.5% ,82. 4% ,88.2% respectively, and no significant difference were observed （P 〉0.05）. The positive rates of bag- 1 expression between breast cancer with axillary lymph node metastasis and that without axillary lymph node metastasis were 89.6% ,78.6% respectively, and no significant difference was observed （P 〉0.05）. Conclusion There is an overexpression of bag - 1 in breast cancer and the expression is not related to axillary lymph node metastasis.