纤维支气管镜介入微波并局部化疗对晚期肺癌所致气道狭窄的治疗作用

Treatment of airway constriction due to odvanced lung cancer using microwave combined with local chemotherapy via fibro bronchoscope.

目的探讨经纤维支气管镜(纤支镜)介入微波并局部化疗对气道阻塞性晚期肺癌的治疗作用。方法将100例有气道阻塞的晚期肺癌患者,随机分为观察组(50例)与对照组(50例),观察组采用Bestar-Ⅱ型微机控制多功能微波治疗仪经纤支镜介入对瘤体进行点灼,并向瘤体中央及周围注入顺铂30mg,同时用异环磷酰胺、表阿霉素、顺铂(ICE)方案进行全身静脉化疗。对照组单用ICE方案化疗。结果观察组50例中,显效15例(30%),有效26例(52%),无效9例(18%)。有效率82%,明显高于对照组的有效率(36%,P<0.01)。结论经纤支镜介入微波并局部化疗能较快地使肿瘤缩小或消失,肺不张复张。此方法的客观疗效及症状缓解均优于单纯化疗。

Objective To investigate the effect of microwave combined with local chemotherapy via fibro bronchoscope on advanced lung cancer patients. Methods A total of 100 cases of advaned lung cancer patients were divided into observing group （ 50 cases ） and control group randomly. The observing group were treated through endotracheal tumor microwave burning and cisplatin local injection via fibro bronchoscope using Bestar Ⅱ type computer controlled treatment instrument, meanwhile intravenous chemotherapy was performed （ treatment program was ICE： ifosfamide, adriamycin, cisplatin ）. The control group were only treated with ICE regimen chemotherapy . Results In observing group（50 cases） ;15 cases were the apparent response （30% ） ;26 cases were response （52% ） ;9 cases were nonrespeuse （ 18% ）, the total effective rate was 82%. The effective rate was much higher than the control group （36% ）, P 〈0. 01. Conclusion Local microwave combined with local chemotherapy through fibro bronchoscope intervene can quickly decrease tumor size or eliminate tumor, expanded the atelectasis and relieve patient dyspnea. The objective effect and symptom remission rate of this new combining method is better than the simple cheomotherapy.