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肺癌常用化疗药物相关的抗药标志研究进展 被引量:5

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摘要 化疗是肺癌治疗的主要手段,耐药是影响化疗疗效的重要因素。研究表明一些基因的突变或表达水平增高及多态性使肿瘤对药物产生耐药是影响药效的一个重要因素。以下对肺癌常用化疗药物铂类、紫杉类、吉西他宾抗药相关的分子标志如XPD,β-tubulin,RRM1等近年来的研究进展进行综述。
出处 《现代肿瘤医学》 CAS 2006年第3期352-354,共3页 Journal of Modern Oncology
基金 首都医学发展基金资助(编号2003-3028)
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参考文献14

  • 1Rosell R.Predictive molecular markers in non-small cell lung cancer[J].Curr Opin Oncol,2001,13:101~109.
  • 2Rosell R.Predicting response to Paclitaxol/Carboplatin -based therapy in NSCLC[J].Seminars in oncology,2002,28(4suppl 14):37~44.
  • 3Rosell R.Pharmacogenomic research and serum DNA analysis in the treatment of non-smsll cell lung cancer[J].Rev Oncologia,2001,38:60~71.
  • 4Kumagai A,Dunphy WG.Purification and molecular cloning of Plx1,a Cdc25-regulatory Kinase from Xenopus egg extracts[J].Science,1996,273(6):1377~1380.
  • 5Rosell R.Determinants of response and resistance of cytotoxics[J].Semin Oncol,2002,291 suppl(4):110~118.
  • 6Hou SM,Ryk C,Kannio A,et al.Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors[J].Environ Mol Mutagen,2003,41(1):37~42.
  • 7Hu Z,Wei Q,Wang X,et al.DNA repair gene XPD polymorphism and lung cancer risk:a meta-analysis[J].Lung Cancer,2004,46(1):1~10.
  • 8HDavid J,Park,Stoehlmacher J,et al.A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum -based chemotherapy in patients with advanced colorectal cancer[J].Cancer Research,2001,15:8654~8658.
  • 9Camps C,Sarries C,Roig B.Assessment of nucleotide excision repair XPD polymorphisms in the peripheral blood of gemcitabine/cisplatin-treated advanced non-small-cell lung cancer patients[J].Clin Lung Cancer,2003,4(4):237~241.
  • 10Rosell R,Crino L,Danenberg K.Targeted therapy in combination with gemcitabine in non-small cell lung cancer[J].Semin Oncol,2003,30(4 Suppl 10):19~25.

同被引文献72

  • 1刘爱国,李同度.癌症恶病质研究进展[J].癌症进展,2003,1(2):126-130. 被引量:7
  • 2吴冰,张立潮,张惠中.Stathmin蛋白的研究进展[J].中国肿瘤生物治疗杂志,2005,12(1):71-73. 被引量:4
  • 3侯振江,张宗英.瘦素测定的临床应用进展[J].医学综述,2006,12(3):188-190. 被引量:7
  • 4李丹,曾波航,于宪.血清瘦素和TNF-α与恶性肿瘤恶液质的关系[J].实用肿瘤学杂志,2006,20(1):7-8. 被引量:8
  • 5肖永营,宋勇,施毅.NSCLC化疗敏感性的分子指标及临床意义[J].临床肿瘤学杂志,2006,11(11):867-869. 被引量:3
  • 6Hou SM, Ryk C, KannioA, et al. Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors[J].Environ Mol Mutagen, 2003, 1 (41) : 37 -42.
  • 7Hemminki K,Xu G, Angelini S,et al. XPD exon 10 and 23 polymorphisms and DNA repair in human skin in situ[J]. Carcinogenesis,2008,22( 15 ) :1185 - 1188.
  • 8Zhou W, Gurubhagavatula S, Liu G,et al. Excision repair crosscomplcmentation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy[J].Clin Cancer Res, 2004, 10 (15) : 4939 -4943.
  • 9Simon GR, Sharma S, Cantor A, et al. ERCC1 expression is a predictor of survival in resected patients with nonsmall cell lung cancer[ J ]. Chest,2005, 3 ( 127 ) :978 - 983.
  • 10Lord RV, Brabender J, Gandara D, et al. Low ERCC 1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in nonsmall cell lung cancer [ J ]. Clin Cancer Res ,2007.8 ( 13 ) : 2286 -2291.

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