中山市健康人群麻疹抗体水平监测分析

Surveillance and Analysis on Measles Antibody Level in Zhongshan City

目的了解中山市健康人群麻疹免疫状况。方法对242人(其中常住人群155人,外来流动人群87人,按防疫人群监测共分三组(2～4岁、6～8岁、13～15岁),采用酶联免疫吸附试验(ELISA)方法检测麻疹IgG抗体滴度。结果中山市健康人群麻疹抗体总阳性率为92.1%,其中中山市常住人群麻疹抗体阳性率为98.1%,外来流动人群阳性率为81.6%,麻疹抗体阳性率相差有极显著性意义(!2=31.00,P<0.001)。本地常住人群和外来流动人群麻疹抗体免疫水平抗体滴度分别为1181.1、270.2,相差也有极显著性意义(t=5.54,P<0.01)。结论中山市健康常住人群麻疹抗体阳性率和免疫水平均处于较理想状态,已形成较牢固的免疫屏障,而外来流动人群情况较差,应加强外来流动人群规范管理,及时按计划接种疫苗,防止麻疹的暴发流行。

Objective The aim of this study was to observe the measles antibodies among normal population in Zhongshan city. Method Enzyme linked immunosorbent assay （ELISA） was used for the qualitative detection of IgG antibodies to measles virus. Results The results showed that the positive rates of IgG antibodies to measles virus was 92.1% in Zhongshan city. The positive rates were as foUows：the native crowd, 98.1%; the outside crowd 81.6%. The GMRT were as follows： the native crowd, 1181.1; the outside crowd was 270.2. The positive rates and the GMRT were difference in different crowd （native and outside）. Anti-measles IgG antibodies showed a significant increase in both groups（the positive rates： X^2=31.00, P〈0.001; the GMRT： t=5.54, P〈0.01）. Conclusion These data indicated that measles routine immunization was not satisfactory in the outside crowd of Zhongshan city. We suggest to strengthen the routine immunization to raise the immunization coverage rate.