血浆置换术治疗大剂量激素及免疫抑制剂疗效不佳的重症自身免疫性疾病

Treatment for serious autoimmune disease with plasma exchange therapy after suboptimal response to large doses of steroids

目的探讨血浆置换术(PET)在大剂量激素及免疫抑制剂疗效不佳的重症自身免疫性疾病治疗中的作用。方法 23例大剂量激素及免疫抑制剂疗效不佳的重症自身免疫性疾病患者连续做血浆置换3～5次。结果 23例患者化验指标和临床症状均明显改善,置换前与置换后血沉、球蛋白、抗核抗体之间差异均有显著意义。结论 PET对大剂量激素及免疫抑制剂疗效不佳的重症自身免疫性疾病疗效肯定,安全性高。

Objective： To investigate the effect of plasma exchange therapy（PET） for serious autoimmune disease after suboptimal response to large doses of steroids and immune inhibition. Methods： Twenty- three patients with serious autoimmune disease received PET for 3 to 5 times continuously after suboptimal response to large doses of steroids and immune inhibition. Results： The examination indexes and clinical symptoms were improved significantly; The erythrocyte sedimentation rate, globulin and anti nucleus antibody levels after PET were markedly lower than those before PET. Conclusion： PET is effective and .safe in treating serious autoimmune disease after suboptimal response to large doses of steroids and immune inhibition,