复方虫草精华(Lungfit)对大鼠血液循环功能的影响

Effect of Lungfit on Hemato-Circulatory Function in Rats

目的观察复方虫草精华(Lungfit)对大鼠血液循环功能的影响。方法Lungfit(80、160、325mg/kg/d),连续灌胃给药10d后,分别测定外周血中红细胞数和血红蛋白含量等;Luugfit(160、325mg/kg/d),连续灌胃给药10d后,取心脏,用Langendorff装置逆行恒压灌流,分别测定缺血前后各组心脏的心功能参数值。结果Lungfit灌胃能不同程度地增加大鼠血液中红细胞数、血红蛋白含量等(P<0.05或P<0.01),但低剂量组与对照组相比,差异不显著(P>0.05);缺血前,Lungfit灌胃大鼠离体心脏的各项心功能参数值与对照组相比无显著差异(P>0.05);缺血30min后的再灌注期间,Lungfit灌胃大鼠心脏的心肌舒缩功能改善明显优于对照组(P<0.05或P<0.01)。结论Lungfit能改善外周血象并对心肌缺血/再灌注损伤具有保护作用。

Objective To study the effect of Cordyceps sinensis compound（Lungfit） on Hemato-circulatory function in rats. Methods In this papcr, rat erythrocyte count and hemoglobin were studied after intragastric administration of three different doses of Lungfit （80,160,325mg/kg/d）for 10 days. Langendorff perfusion technique of rat heart was used to detect the myocardial function parameter at every 5 min intervals before ischemia and after reperfusion.Lungfit was administered by intragastric gavage at two different doses （160,325 mg/kg/d） for 10 days consecutively. Results Lungfit of different doses could prolong the rat increase the number of erythrocytes and the content of hemoglobin.But there was no significant difference between the low dose group and the control group（P〉0.05）.No statistical difference was observed between the Lungfit group and the control group before ischemia（P〉0.05）.However, in the reperfusion period after 30 min global ischemia, the recovery of systole/diastole function was markedly superior to that of control group.Conclusion The Lungfit could enhance the protective effect on hemogram and on myocardial ischemia/reperfusion injury.