喹诺酮类药物致老年患者神经系统不良反应分析

Analysis on Adverse Drug Reactions of Nervous System of Fluoro-quinolones in Elderly Patients

目的分析120例老年患者应用喹诺酮类药物引起神经系统的不良反应(adversedrugreaction,ADR)特点。方法从历年的患者ADR报告中,选出60岁以上的老年患者ADR报告表,逐项统计整理。结果老年患者神经系统ADR男多于女,严重程度以轻、中度多见;老年患者神经系统ADR临床表现以头晕、失眠为主,最易引起神经系统ADR的药物为左氧氟沙星;静脉用药最易引起神经系统的ADR。结论老年患者在喹诺酮类药物治疗中,神经系统的不良反应与老年患者的年龄、给药途径密切相关。

Objective To analyze adverse drug reactions of nervous system and its related factors in 120 elderly patients. Methods ADR reporting forms over years of our hospital were collected and reviewed. Patients with ADR were over 60 years old. Results ADR of nervous system in elderly patients occurred more in male than in female. Most cases had light or medium reaction;most of the ADR by fluoroquinolones were dizziness and insomnia.They ranked firstly and secondly respectively on the ADR order list. ADR of nervous system by Levofloxacin is more common than other fluoroquinolones; ADR in intravenous infusion occurred more commonly than other way of administration. Conclusions Occurrence of ADR of nervous system in the treatment by fluoroquinolones in the eldery patients is in close relation with their age and the way of administration.