M-AST检测对急性肝炎预后判断的意义

Prediction of M-AST in Prognosis of Acute Hepatitis

目的观察M-AST活性测定在急性肝炎治疗预后的意义。方法观察了73例急性肝炎急性期和恢复期的M-AST活性变化,同时观察其它疾病组疾病的急性期和恢复期M-AST的变化。结果急性肝炎急性期M-AST100%增高(130±21),治疗两周明显下降,90%的患者M-AST降至40±10.2;恢复期73例患者71例降至正常,2例持续升高最终变为慢性迁延性肝炎,其它疾病组急性期、恢复期无变化(6.9±2.5,4.5±3.1)。结论M-AST是急性肝炎恢复的一个客观指标,急性肝炎到恢复期,M-AST全部下降,预后良好。否则病程牵延,最终变为慢性肝炎。

Objective To assess M-AST Level in Patients with acute hepatitis and to evaluate its significance as predictor of prognosis. Methods This study comprised 73 patients suffering from acute hepatitis confirmed by serology.We compared the M-AST level during acute and convalescent stage.Meanwhile,the M-AST of patients with other disease were also detected. Results The mean M-AST concentrations of the patients with acute hepatitis during acute stage were all elevated significantly（130 ± 21）.After two weeks＇ therapy, the M-AST of 90 % patients decreased（40 ± 10.2）.During convalescent stage,M-AST was declined to normal level mostly（71 cases, 90%）.In contrast,the other two cases were still high and developed to chronic hepatitis.The M-AST of the patients with other disease has no significant change in acute（6.9 ± 2.5）or convalescent （4.5 ±3.1） stage.Conclusions The present study shows that the M-AST level of acute hepatitis patients seems to be a sensitive criterion to determine the prognosis of the patients.During convalescent stage,high level of M-AST means unfavourable prognosis.