5-HT2A受体基因T102C遗传多态性与迟发性运动障碍的关联研究

An Association Study on Serotonin-2A Receptor Gene T102C Genetic Polymorphism and Tardive Dyskinesia

目的探讨广东地区汉族人群中5-HT2A受体基因T102C多态性的分布与迟发性运动障碍(TD)的关联性。方法采用病例-对照研究。应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测65例伴有TD和59例无TD的精神分裂症患者5-HT2A受体基因T102C多态性分布,比较两组间基因型和等位基因频率的差异。结果经2χ检验,T102C基因型与等位基因频率在两组间未见显著性差异(P>0.05)。结论本研究中未发现广东地区汉族人群中5-HT2A受体基因T102C多态性与迟发性运动障碍存在关联。

Objective To investigate the relationship between serotonin 2A receptor gene T102C genetic polymorphism and tardive dyskinesia （TD）. Methods The Polymerase Chain Reaction -Restriction Fragment Length Polymorphism （PCR-RFLP） technique was used to detect 5-HT2A T102C polymorphism in 65 schizophrenic with TD and 59 without TD. The differences in genotype and allele frequency were compared with chi-square test. Results No significant differences in genotype and allele frequencies were found between TD and Non-TD groups. Conclusions 5-HT2A T102C Polymorphism is not associated with tardive dyskinesia in our sample.